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Compounds and Methods for the Detection of Hydrogen Peroxide

Compounds and Methods for the Detection of Hydrogen Peroxide
Research Tools and Methods

Background and Market Opportunity

  • Hydrogen peroxide plays a crucial role in oxidative stress and signal transduction in organisms.
  • In order to investigate the reaction mechanisms of hydrogen peroxide, analytical approaches using chemiluminescence and fluorescence probes have been developed to detect its intracellular generation.
  • There are commercially available fluorescence probes for hydrogen peroxide detection analysis, for example, Amplex Red reagent has been used to detect the release of hydrogen peroxide from activated human leukocytes.
  • However, many commercially available fluorescence probes suffer from drawbacks, such as slow response time and sensitivity, making tracking hydrogen peroxide in situ difficult.

Technology Overview and Key Advantages

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  • This invention employs a new chemistry, to provide an ultra-efficient and novel mechanism for H2O2 detection, thus escalating the sensitivity and selectivity toward H2O2 and avoiding the interference from cellular ROS/RNS.


  • Rapid-response.
  • Highly selective in situ, in vivo, and in vitro.
  • High sensitivity and selectivity towards hydrogen peroxide.
  • Can avoid the interference from cellular ROS/RNS.
  • Highly robust performance in multiple cell types.

Potential Product and Applications

  • Detection methods for drug screening, cancer screening and disease diagnosis.
  • Investigate tumor initiation, progression and metastasis.

Development Status and IP Strength

  • PCT application filed

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