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Combination of Polymyxin Antibiotic and Mobile Colistin Resistant Protein Inhibitor for Treating Superbug

Combination of Polymyxin Antibiotic and Mobile Colistin Resistant Protein Inhibitor for Treating Superbug
Field
Therapeutic Chemicals
Patent
IP00856

Key Problem and Market Opportunity

Colistin was used as “last hope” treatment against Gram-negative bacterial infection. However, rapid global resistance towards colistin has emerged. Therefore, there is an urgent need for colistin resistance treatment.

Key Advantages of the Technology

Technology Section Slider 1
Technology Section Slider 2
  • Gold or silver compounds will work as the mobile colistin resistant proteins inhibitor
  • Antibiotics can then enter bacteria with the assistant of such inhibitor ()

Further Details

Runming Wang et al., NATURE COMMUNICATIONS | (2020) 11:5263

Benefits

  • Broad spectrum against both carbapenem and colistin resistant bacterial strains
  • Can take the advantages of drug repurposing

Potential Product and Services

Drugs for anti-bacteria, especially for treating mobile colistin resistant proteins carrying bacterial infection

Development Status and IP Strength

Patents
  • PCT publication no, WO/2021/036923
IP Status
  • Patent application submitted

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